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Shaik Parveen1, G. Mahaboob Basha*2
1M. Pharm Student, Department of Pharmaceutics, Prabhath Institute of Pharmacy, Parnapally (Vil.), Bandiatmakur (MD), Nandyal Dist., Andhra Pradesh
2Associate Professor, Department of Pharmaceutics, Prabhath Institute of Pharmacy, Parnapally (Vil.), Bandiatmakur (MD), Nandyal Dist., Andhra Pradesh
A B S T R A C T
Conventional therapy available for lung cancer has untended consequences and oral dosage forms has limitations such as low bioavailability of drug due to first pass metabolism which need high dose to treat disease. Polymeric micelles’ low toxicity and quick rate of bodily elimination make them excellent for intravenously given drug delivery systems. Additionally, the chemical makeup of the medications does not need to be changed. The study was undertaken for development and characterization of Cabazitaxel loaded lyophilized block co-polymeric micelles for treatment of cancer therapy with effective use of Pluronic F127 and TPGS in polymeric micelles to improve Cabazitaxel solubility. Formulation CBT9 has the highest entrapment rate at 79.12 percent, as the quantity of polymer increases, fraction of drug loading and entrapment also enhances, which is related to the production of additional micelles over the CMC value. The optimized batch’s Z averages were 103.5 and 113.6 nm, respectively, with PDI of 0.011 and 0.055. At pH 5.5, Cabazitaxel-loaded polymeric micelles release 87.49 percent of the drug. At pH 7.4, Cabazitaxel-loaded polymeric micelles release 83.19 percent of the drug.
Keywords: Cabazitaxel, Polymeric micelles, CMC, Pluronic co-poymer, Pluronic F68, Pluronic F127 etc
