Evaluation of antidiabetic activity of ethanolic extract of Polyalthia Suberosa Roth in alloxon induced diabetic rats.

Saritha Chandra*, M. Divya Sigh, K. Madhu, D. Lakshmi Prasanna, P. Reshma Sai, V. Mary
Jagan’s college of Pharmacy, Jangala Kandriga, Nellore, Andhra Pradesh, India

A B S T R A C T
Polyalthia suberosa Roth species have been extensively used for the management of diabetes in folklore medicine. The current study was designed to investigate the antidiabetic and antihyperlipidemic effects of Polyalthia suberosa. Ethanolic extracts of Polyalthia suberosa were tested for their antidiabetic potentials in diabetic rats. The effect of extracts was observed by checking the biochemical, and histopathological parameters in diabetic rats. The ethanolic at doses of 200 and 400mg/kg b. w significantly reduced glucose levels in diabetic rats. The other biochemical parameters like cholesterol, triglycerides, low density lipoproteins (LDL), serum creatinine, serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), and alkaline phosphatise (ALP), were found to be reduced by the ethanolic extracts. The extracts also showed reduction in the feed and water consumption of diabetic rats when compared with the diabetic control. The histopathological results of treated groups showed the regenerative/protective effect on ?-cells of pancreas in diabetic rats. The current study revealed the antidiabetic potential of Polyalthia suberosa being effective in hyperglycemia and that it can effectively protect against other metabolic aberrations caused by diabetes in rats, which seems to validate its therapeutic traditional use.
Keywords: Antidiabetic, Polyalthia suberosa, Alloxan