Evaluation of Anti-Dandruff Activity of Citrullus Lanatus (Watermelon) Seeds

K. Sumanth Kumar*, G. Sai Kishore, K. Sivani, J. Sujitha, K. Jyoshna, SK. Reshma
Ratnam Institute of Pharmacy, Pidthapolur (V), Muthukur (M), Nellore (Dt), Andhra Pradesh – 524343, India

A B S T R A C T
Dandruff is a chronic scalp condition characterized by scaling, itching and redness of the scalp. It occurs when scalp sheds epidermal cells in large clumps. The skin of scalp renews itself about once a month. Usually, scalp sheds dead cells in nearly invisible way, but sometimes cell turnover becomes unusually rapid and dead cells are shed as visible flakes called dandruff. Seed extracts have emerged as promising sources of bioactive compounds with notable antioxidant and antibacterial properties, primarily attributed to their rich content of phenolic and polyphenolic components. These bioactive compounds exhibit significant potential as therapeutic agents for managing disorders associated with oxidative stress and combating infectious diseases. The antioxidant capabilities of seed extracts are particularly noteworthy, as oxidative stress plays a pivotal role in the pathogenesis of various health conditions. Phenolic and polyphenolic compounds present in these extracts have demonstrated the ability to neutralize reactive oxygen species (ROS) and free radicals, which are implicated in cellular damage and the progression of oxidative stress- related disorders. The bioactive chemicals found in the sample have been shown to have pharmacological and physiological properties. These seeds contain significant free radical scavenging activity and consequently antioxidant activity, according to our research. The amount and kind of bioactive compound produced by medicinal plants determine its anti-ailment action and different physiological impacts on the human body system. The seed extracts represent a rich source of bioactive compounds with substantial antioxidant and antibacterial properties, mainly attributed to their phenolic and polyphenolic components. The exploration of these compounds as potential therapeutic agents holds great promise for managing oxidative stress-related disorders and combating infectious diseases. As research in this field continues to advance, the identification, isolation, and mechanistic understanding of seed-derived bioactive compounds will undoubtedly contribute to the development of novel treatments and interventions in the realm of medicine.
Keywords: antioxidant, reactive oxygen species (ROS), polyphenolic, Citrullus Lanatus, bioactive compounds