Evaluation of anthelmintic and In-vitro antioxidant Activities of plectranthus amboinicus

Garla Venkateswarlu*¹, Dr. P. Venkatesh², Dr. Hepcy kalarani³, E. Rajani⁴, M.P Vijay Kumar^5
1Assistant professor, Dept. of pharmaceutical chemistry, Jagan’s College of Pharmacy, Nellore, A.P, India.
²Principal, Depatrment of pharmaceutical chemistry, Jagan’s College of Pharmacy, Nellore, A.P, India.
³HOD & Professor, Dept. of pharmaceutical chemistry, Jagan’s College of Pharmacy, Nellore, A.P, India.
⁴Assistant professor, Depatrment of pharmacology, Jagan’s College of Pharmacy, Nellore, A.P, India.
⁵Assistant professor, Depatrment of pharmaceutics, Jagan’s College of Pharmacy, Nellore, A.P, India.

A B S T R A C T
Now a day’s herbal medicinal plants are play a key role in the development of potent therapeutic agents. Plant based drugs provide excellent contribution to modern therapeutics. Herbal medicines are used to their safety, efficacy and lesser side effects. These drugs are made from renewable sources of raw materials by ecofriendly processes and will bring economic prosperity to the masses. The present study was carried out in the plant of Plectranthus amboinicus. Commonly known as coleus amboinicus and oregano having several pharmacological properties including antibacterial, antioxidant, antitussive, anti-diabetic, antiulcer, antiseptic, Hepatoprotective, rheumatism, skin ulceration, helminthiasis and epilepsy have been reported for this plant. The present works were carried out to evaluated in-vitro antioxidant and in-vivo anthelmintic activity of Methanol extracts of roots of Plectranthus amboinicus. Extracts were screened for their chemical constituents methanol extracts shows the presence of phenols, alkaloids, amino acids, flavonoids, triterpinoids, tannins and glycosides. The antioxidant activities were measured using H₂O₂ scavenging activities. In antioxidant studies methanol extract shows the significant activity in H₂O₂ scavenging method then the standard. In anthelmintic activity methanol extract had significant activity when compared to standard drug albendazole by using Pheretima posthuma.
Keywords: Plectranthus amboinicus, H₂O₂, Ascorbic acid, Pheretima posthuma, albendazole.