Effect of polymers in release rate of Metoprolol succinate in pulsatile release tablets

About author
Sravanthi B, Dr. Hindustan Abdul Ahad*, Naresh babu G
PG department of Industrial Pharmacy, Balaji College of Pharmacy, Anantapur, AP, India
E-mail: abdulhindustan@rediffmail.com

Abstract
The objective of the present investigation was to develop and evaluate an oral pulsatile drug delivery system. The design of the system consisted of a rapid release tableted core and a controlled release tableted coat. The core layer consists of Metoprolol Succinate and coating layer consists of Benecil K 200M, HPMCK 100 M and Eudragit RSPO. The compatibility of Metoprolol Succinate with polymers used was performed by FTIR studies. The prepared tablets passed the pre compression and post compression evaluation characteristics. An in vitro dissolution study of the prepared tablet was conducted initially for 2 h in simulated 0.1 N HCl and after that medium was changed to acetate buffer pH 4.5 for 4h finally in phosphate buffer pH 6.8. The in vitro data was further treated with mathematically toknow the rate of release. The study concluded the F6 formulation showed compliance with circadian rhythm.
Keywords: Metoprolol Succinate, Pulsatile tablets, Benecil K 200M, HPMCK 100 M
Introduction
Oral dosage forms are promising, safe and convenient drug delivery systems since past few decades. The controlled release drug delivery systems with reservoir or matrix systems release the active drug for extended period of time. Chronopharmaceutics, the drug delivery based on circadian rhythm, is recently gaining much attention worldwide. Various diseases like asthma, hypertension and arthritis show circadian variation, that demand time scheduled drug release for effective drug action. Results of several epidemiological studies have demonstrated the elevated risk of different pathologies during a 24 h cycle. Blood pressure which rises notably just before waking up is usually responsible for attacks. New technology based on pulsatile release control was developed to satisfy this requirement. Metoprolol tartarate is selective β adrenoreceptor blocking agent used to treat hypertension, angina and heart attack.The aim of the present work is to develop pulsatile drug delivery system tablets using core and coating layers. The core layer consists of Metoprolol Succinate and coating layer consists of Benecil K 200M, HPMCK 100 M and Eudragit RSPO.