Development and Validation of new analytical methods for the estimation of Lacosamide by UV Spectroscopy

P. Gobala krishnan*¹, Vonteru Muni Sekhar², V. Hemanth Kumar³, G. Sadik^4
1Professor and Principal, Vagdevi College of Pharmacy and Research Centre, Brahmadevam Village, Muthukur Mandal, Nellore -524346.
^2,3Associate Professor, Vagdevi College of Pharmacy and Research Centre, Brahmadevam Village, Muthukur Mandal, Nellore -524346.
⁴Assistant Professor, Vagdevi College of Pharmacy and Research Centre, Brahmadevam Village, Muthukur Mandal, Nellore -524346

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rapid and sensitive UV-Visible spectroscopic method was developed for the estimation of Lacosamide in bulk and its pharmaceutical formulation. The method was validated as per International Conference on Harmonization [ICH] guidelines. The Lacosamide was monitored at 230 nm with UV detection and there is no interference of diluent at 230 nm for lacosamide. The method was linear (r²=0.999) at concentration ranging from 12 to 40μg/mL, precise (intra and inter-day RSD values < 1.0%), accurate (mean recovery = 99.9%), specific and robust. The results showed that the proposed method is suitable for the precise, accurate and rapid determination of lacosamide in bulk and tablet dosage forms.
Keywords: Lacosamide, UV-Visible spectroscopy, Validation, Dosage form

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