Design development and evaluation of 5-fluorouracil gel

Reshma Bhanu Dudekula*, Venkata Ramana Bachu, Venkata Badarinath Atluri
Dr. K. V. Subba Reddy Institute of Pharmacy, Kurnool, Andhra Pradesh, India – 518218

A B S T R A C T
Controlled Drug Delivery Systems (CDDS) in recent years there has been a growing interest in subject of drug delivery and design and evaluation of controlled release systems. These are more sophisticated systems can be used as a means of altering the pharmacokinetic behavior of drugs in order to provide twice or once a day dosage. The basic approach used in development of Floating insitu gel is the use of natural gums which provide instantaneous viscosity in the presence of fluid and there by releasing on floating with the help of bicarbonates in stomach. 5-Fluorouracil is an anti-neoplastic agent used in the treatment of many types of cancers. Floating insitu gel of 5-Fluorouracil was prepared by using Sodium alginate, Guar gum by general orderly mixing methods. Change in the concentration of sodium alginate made the drug release changed to the extent of understanding. FTIR studies revealed that there is no chemical incompatibility between the drug and other excipients used in the formulation development.
Keywords: 5-Fluorouracil, Anti-Neoplastic, Sodium Alginate, Guar Gum