Design, Characterization and Evaluation of Cefaclor Microspheres by Solvent Evaporation Method

Mallikarjun V.^1*, Sriharsha S.N.¹, D. Yashwanth Kumar^2
1Pacific College of Pharmacy, Pacific University, Udaipur, Rajasthan, India
²Scientific and Applied Research Center, Hyderabad, Telangana, India.

A B S T R A C T
The aim of the present study was to develop and characterize cefaclor microspheres containing ethyl cellulose as a sustained release delivery system. Cefaclor microspheres are prepared by solvent evaporation technique. Microspheres were found to be intact and spherical shape. Their particle size range was 178.0 to 245.3 µm. Scanning electron microscopy shoed spherical shape of microspheres. The loading efficiency showed maximum value when the concentration of cefaclor and ethyl cellulose was 1:4. Best retardation of cefaclor release from ethyl cellulose in all formulations were showed, but formulation CF1 is the optimized formulation the drug release showed 94.71% up to 12 hrs and order of release was zero order, it was best fitted in the Korsmeyer Peppas model.
Keywords: Microspheres, ethyl cellulose and solvent evaporation