Chronopharmacokinetics: As Targetted Drug Delivery for Rheumatoid Arthritis by PDDS

ABOUT AUTHOR
A. Srikanth^1*, Y. Prasanna Raju², N. Devanna³, Kambham Venkateswarlu^4
1Department of Pharmacology, Oil Technological Research Institute, Anantapur-515001, A.P, India.
²Department of Pharmaceutics, Sri Vidyanikethan College of Pharmacy, Tirupati-517102, A.P, India.
³Department of Chemistry, Oil Technological Research Institute, Anantapur-515001, A.P, India.
⁴Department of Pharmaceutics, Oil Technological Research Institute, Anantapur-515001, A.P, India.

Abstract
The main aim of this review is “how to target the Rheumatoid Arthritis by Pulsatile Drug Delivery System through chronopharmacokinetic information”. The patients who are suffering from Rheumatoid Arthritis will have pain at morning time. Due to this chronopharmacokinetic studies, this gives the information about variation in drug plasma levels as a function of time usually 24 hours and the mechanism responsible for that time dependent variation. So now the targeted drug delivery will happen in that patients and they will be free from the pain rapidly. PDDS releases the drug for prolonged period of time, especially after the lag time.
Key words: Chronopharmacokinetics, Rheumatoid Arthritis, PDDS.