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About author: Ramesh Dhani Dept. of Pharmaceutical Chemistry JNTUA – OTRI, Anantapur, India E-mail: dhanipharmachem@gmail.com ABSTRACT: In the past two decades, a wide variety of bioactive peptides have been discovered. Many of the heterocyclic found to exhibit antifungal, antibacterial, cytotoxic, antineoplastic, insecticidal, anti-inflammatory, tyrosinase inhibitory and melanin production inhibitory activities. Imidazole has been drawn as promising structural units in the ... Read More »
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Category Archives: Chemical Sciences and Chemical research
Synthesis and characterization of 3-[(5-phenyl hydroxyl-1, 3, 4-oxadiazol-2-yl) methyl amino]-2-methyl quinazolin-4(3h)-one
About author: Ramesh Dhani Dept. of Pharmaceutical Chemistry JNTUA – OTRI, Anantapur, India E-mail: dhanipharmachem@gmail.com ABSTRACT: Quinazolinone is a heterocyclic compound. There are two structural isomers, 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common. Various novel classes of structurally different quinazolinones have been designed and synthesized depicting potential interventions such as antibacterial, antifungal, antiviral, anticonvulsant, CNS depressant, anti-inflammatory, ... Read More »
SYNTHESIS AND CHARACTERIZATION OF 4-[2′-(5′-NITRO) IMIDAZOLYL] BENZOYL (N-ME) VALINE
About author : Ramesh Dhani Dept of Pharmaceutical Chemistry JNTUA-OTRI, Anantapur, India E-mail : dhanipharmachem@gmail.com ABSTRACT: Many of the heterocyclic found to exhibit antifungal, antibacterial, cytotoxic, antineoplastic, insecticidal, anti-inflammatory, tyrosinase inhibitory and melanin production inhibitory activities. Imidazole has been drawn as promising structural units in the field of medicinal chemistry. Introduction of D-amino acids and N-methylation of amino acids like ... Read More »
SYNTHESIS AND CHARACTERIZATION OF 4-[2′-(5′-NITRO) IMIDAZOLYL] BENZOYL (N-ME) TYROSINE
About author : Ramesh Dhani Dept. of Pharmaceutical Chemistry JNTUA-OTRI, Anantapur, India E-mail: dhanipharmachem@gmail.com ABSTRACT: Introduction of D-amino acids and N-methylation of amino acids like tyrosine, valine, alanine etc enhanced antimicrobial activity. Condensation of heterocyclic moieties viz nicotinic acid, thiazole, coumarin, quinoline, furan, imidazole etc. with amino acids and peptides resulted in compounds with potent biological activities. Many of the ... Read More »
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF 4-[2′-(5′-NITRO) IMIDAZOLYL] BENZOYL(N-Me) AMINO ACID DERIVATIVES
About author : Ramesh Dhani Dept. of Pharmaceutical Chemistry JNTUA-OTRI, Anantapur, India E-mail: dhanipharmachem@gmail.com ABSTRACT: A great number of drugs are heterocyclic compounds, mostly are of synthetic origin, few have obtained from natural resources which include alkaloids, xanthines, cardiac glycosides, vitamins and several antibiotics. Heterocyclic derivatives having two nitrogen atoms oriented in, 1-3 position are endowed with wide spectrum of ... Read More »
SYNTHESIS, CHARACTERIZATION AND ANTHELMINTIC ACTIVITY OF 4-[2′-(5′-NITRO) IMIDAZOLYL] BENZOYL (N-METHYL) AMINO ACID DERIVATIVES
About author : Ramesh Dhani Dept. of Pharmaceutical Chemistry JNTUA – OTRI, Anantapur, India E-mail : dhanipharmachem@gmail.com ABSTRACT: Compound containing the imidazole ring are very important in living system, such as vitamin B12 and several pilocarpin alkaloids. Condensation of heterocyclic moieties viz nicotinic acid, thiazole, coumarin, quinoline, furan, imidazole etc. with amino acids and peptides resulted in compounds with potent ... Read More »
Synthesis and Characterization of 4-[2′-(5′-Nitro) imidazolyl] benzoyl (N-Me)Phenyl alanine
About author : Ramesh Dhani Dept. of Pharmaceutical Chemistry JNTUA-OTRI, Anantapur, India E-mail: dhanipharmachem@gmail.com ABSTRACT: In the past two decades, a wide variety of bioactive peptides have been discovered. Many of the heterocyclic found to exhibit antifungal, antibacterial, cytotoxic, antineoplastic, insecticidal, anti-inflammatory, tyrosinase inhibitory and melanin production inhibitory activities. Imidazole has been drawn as promising structural units in the field ... Read More »
Synthesis and characterization of 3-((5-phenyl-1, 3, 4-oxadiazol-2-yl)Methyl amino)-2-methyl quinazolin-4(3H)-one
About author : Ramesh Dhani JNTUA – OTRI, Anantapur, India Dept.of Pharmaceutical Chemistry E-mail: dhanipharmachem@gmail.com ABSTRACT: Quinazolinone is a heterocyclic chemical compound. There are two structural isomers, 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common. Various novel classes of structurally different quinazolinones have been designed and synthesized depicting potential interventions such as antibacterial, antifungal, antiviral, anticonvulsant, CNS depressant, ... Read More »
SYNTHESIS AND PHYSICO-CHEMICAL ANALYSIS OF 2-SUBSTITUTED BENZOXAZOL – 5-CARBOXYLIC ACID ARYLIDENE HYDRAZIDES
About author : Ramesh Dhani JNTUA-OTRI, Anantapur, India Dept. of Pharmaceutical Chemistry E-mail: dhanipharmachem@gmail.com ABSTRACT: Oxazole is the parent compound for a vast class of heterocyclic aromatic organic compounds. These are azoles with oxygen and nitrogen separated by one carbon. Oxazoles are aromatic compounds but less so than the thiazoles. Oxazole is a weak base; its conjugate acid has a ... Read More »
SYNTHESIS AND CHARACTERIZATION OF 3-[(5-(4-CHLOROPHENYL) 1, 3, 4-OXADIAZOL-2-YL) METHYL AMINO]-2-METHYL QUINAZOLIN-4(3H)-ONE
About author : Ramesh Dhani Dept. of Pharmaceutical Chemistry JNTUA – OTRI, Anantapur, India E-mail: dhanipharmachem@gmail.com ABSTRACT: Quinazolinone is a heterocyclic chemical compound. There are two structural isomers, 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common. Various novel classes of structurally different quinazolinones have been designed and synthesized depicting potential interventions such as antibacterial, antifungal, antiviral, anticonvulsant, CNS ... Read More »
