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Category Archives: Chemical Sciences and Chemical research

journal of medicinal chemistry,bioorganic and medicinal chemistry letters,medicinal chemistry research,medicinal chemistry book

RP HPLC Method Development and Validation of Imipenem and Cilastatin in Bulk and Pharmaceutical Dosage Forms

K. Satyanarayana1, P Sowjanya2, Dr. G. Vijay kumar3* 1KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. 2KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. 3Professor and Head, Dept. of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. A  B  S  T  R A C T A new method was established ... Read More »

Analytical Method Development and Validation for the Simultaneous Estimation of Alogliptin and Pioglitazone by Using RP-HPLC

H. Pranusha1, Dr. Gampa Vijay Kumar2* 1KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. 2Professor and Head, Dept. of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. A  B  S  T  R A C T A new method was established for simultaneous estimation of Alogliptin and Pioglitazone by RP-HPLC method. The chromatographic conditions ... Read More »

RP-HPLC Method Development and Validation for Simultaneous Estimation of Tiotropium and Salmeterol in Bulk and Pharmaceutical Dosage Forms

MS.CH.Anusha1, Dr.D.Naresh2, Dr. GampaVijayKumar3* 1KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. 2KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. 3Professor and Head, Dept. of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. A  B  S  T  R A C T High-performance liquid chromatography is at present one of the ... Read More »

Pharmacological Evaluation of Pavonia Odorata Willd for Analgesic, Anti-Inflammatory and Anti-Ulcer Activity

G.T. Jyostna1, Murali Sollu2, Dr. Gampa Vijay Kumar3 1,2KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. 2Professor and Head, Dept. of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. A B S T R A C T The plant Pavonia odorata willd (Malvaceae) contains many active ingredients like ageratochromene, palmitic acid, hexahydrofarnesyl acetone, beta-eudesmol ... Read More »

Formulation and evaluation of Fluconazole ophthalmic gel by ion gelation method

B. Syed Salman*1, K. Faizun2 1Department of Pharmaceutics, Mahathi College of Pharmacy, Madanapalle, India. 2Department of Pharmaceutics, P. Rami Reddy Memorial College of Pharmacy, Kadapa, India. A B S T R A C T Developed the novel antibacterial drugs with improved efficacy by using different polymers. the formulation and evaluation of an ophthalmic delivery system of an antibacterial agent Fluconazole, based ... Read More »

Analytical Method Development and Vaidation for Velpatasvir and Sofosbuvir in combined Dosage Form by RP-HPLC

K.Nithiyananthan1*, K.V.S.Prasadarao2 1Research Scholar, Acharya Nagarjuna University, Guntur, Andhra Pradesh 522510. 2Principal, Rahul Institute of Pharmaceutical Sciences and Research, Chirala, Andhra Pradesh 523157. A B S T R A C T The estimation of Velpatasvir and Sofosbuvir was done by RP-HPLC. The Phosphate buffer was pH 3.0 and the mobile phase was optimized with consists of Methanol: Phosphate buffer mixed ... Read More »

Analytical Method Development and Validation For in Vinblastine and Vincristine Combine Dosage Forms by RP–HPLC Method

K.Nithiyananthan1*, K.V.S.Prasadarao2 1Research Scholar, Acharya Nagarjuna University, Guntur, Andhra Pradesh 522510. 2Principal, Rahul Institute of Pharmaceutical Science And Research, Chirala, Andhra Pradesh 523157. A B S T R A C T The chromatographic conditions were successfully developed for the separation of Vinblastine and Vincristine by using XterraC185µm (4.6*250mm) column, flow rate was1ml/min, mobile phase ratio was Phosphate buffer (0.05M) pH4.6: ... Read More »

Analytical Method Development and Vaidation for Ombitasvir and Paritaprevir in Combined Dosage Form by RP-HPLC

K.Nithiyananthan1*, K.V.S.Prasadarao2 1Research Scholar,  Acharya Nagarjuna University, Guntur, Andhra Pradesh 522510. 2Principal, Rahul Institute  of Pharmaceutical Sciences And Research, Chirala, Andhra Pradesh 523157 A B S T R A C T Ombitasvir and Paritaprevir by using Thermosil C18 column (4.0×125mm) 5µ, flow rate was 1ml/min, mobile phase ratio was (70:30 v/v) methanol: Sodium acetate buffer pH 3 (pH was adjusted ... Read More »

Investigation of Cardiac Protective Activity of Methanolic Extracts of Garcinia Indica in Rats

Saini Supraja1, Dr. Nagaraju, M.Kulkarni2, Dr. Vijaya Kumar Gampa3* 1KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. 2Asso. Professor, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. 3Professor and Head, Dept. of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. A B S T R A C T Atherosclerotic heart ... Read More »

Synthesis, Characterization and Biological Evaluation of 2-styrylchromone Derivatives

SK. Asma Thunnisa*, Bodapati Raju Department of Pharmaceutical Chemistry, Vikas College of Pharmacy, Visannapeta, Krishna-521215(Dt), A.P, India A B S T R A C T In this present study of the Design, Synthesis and molecular docking studies of 2-styrylchromone derivatives as novel antioxidant agents was considered chromone as basic fundamental pharmacophore in order to show antioxidant properties. We have performed ... Read More »

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