Antihypertensive activity of the acetatic extract of Morinda morindoides on the arterial hypertension induced by adrenalin in rabbits

Bahi Calixte, Boga Gogo Lucien*, Kouangbé Mani Adrien, N’guessan Jean David, Coulibaly Adama
Department of Biosciences, Biochemical Pharmacodynamy Laboratory, University Félix Houphouët-Boigny, PO Box 582, Abidjan 22-Côte d’Ivoire, Africa.

A B S T R A C T
The aim of this work is to study the effect of the acetatic extract of Morinda morindoides on the arterial hypertension induced by adrenalin in rabbits. With this intention, we studied the effect of the EAC of Morinda morindoides on the blood pressure in healthy rabbits, and then the effects of the EAC Morinda morindoides of on the cardiovascular parameters in rabbits made hypertensive in comparison with those of tenordate, a reference antihypertensive drug. The acetatic extract is obtained after evaporation of the filtrate resulting from homogenization of the ethanolic extract in mixture of ethyl acetate and water. Doses of the acetatic extract of Morinda morindoides (1000 and 2000 mg/kg bw) and of tenordate (10 and 20 mg/kg bw) are admistrated by gavage to healthy rabbits and the blood pressure measured using a sphyngomanometer. For the study of the effect of acetatic extract of Morinda morindoides on arterial hypertension, doses of EAC of Morinda morindoides (1000 and 2000 mg/kg bw) and of tenordate (10 and 20 mg/kg bw) are administrated by gavage to rabbits made hypertensive with adrenalin at 1 mg/kg bw. The EAC of M. morindoides decreased systolic blood pressure, diastolic blood pressure and heart frequency. The hypertension induced by adrenaline (1 mg/kg bw) is completely inhibited by the EAC of M. morindoides at doses of 1000 and 2000 mg/kg bw and Tenordate at 10 and 20 mg/kg bw. The EAC of M. morindoides exerts antihypertensive and hypotensive effects on rabbits.
Keywords: Morinda morindoides, hypertension, antihypertensive, gavage.