A Study on Drug-Drug Interaction between Anti-Hypertensive Drug Combination Amlodipine and Telmisartan on Anti-Diabetic Effect of Glimepiride and Metformin in Normal and Streptozotocin Induced Diabetic Rats

ABOUT AUTHOR
B. Kishore Kumar Reddy¹*, K. Mohan¹, C. Hari Kumar², Dr. Hindustan Abdul Ahad³, B. Mohammed Ishaq^3
1PG Department of Pharmacology, College of Pharmaceutical Sciences, SriKrishnadevaraya University, Anantapur –515001, A.P. India.
²Department of Pharmacology, Vasavi College of Pharmacy, Bhakarapeta, KadapaDist, A.P. India.
³Balaji College of Pharmacy, Anantapur–515001, A.P. India.

Abstract
The aims of this study was to investigate the prevalence and to describe the most frequent potential interactions between antihypertensive drug combination, Amlodipine (AMD) and Telmisartan (TLS) on anti-diabetic effect of Glimepiride (GLP) and Metformin (MTF) combination. Study was conducted in normal rats and Streptozotocin (STZ) induced diabetic rats with oral administration of selected doses of antihypertensive drug combination of AMD and TLS, and antidiabetic drug combination of GLP and MTF with adequate wash out periods in between treatments. Blood samples were collected from rats at regular intervals of time and were analyzed for blood glucose. Amlodipine with Telmisartan combination repeated dose treatment has influence the blood glucose levels in healthy and diabetic rats. They have hypoglycemic property. Therefore it was further suggested that readjustment of dose and frequency of administration of oral anti-diabetic agents may be made when they are used simultaneously with Amlodipine and Telmisartan.
Keywords: Amlodipine, Telmisartan, Streptozotocin, Antihypertensive,  Metformin, Anti-diabetic, Glimepiride,