A Simple UV Spectroscopic Method for the Determination of Metaprolol in Bulk and Tablets

U. Nagamani, P. Suvarna, Anusha B, S. Muneer*, B. Mohammed Ishaq, Dr. Hindustan Abdul Ahad
Department of Pharmaceutical Analysis, Balaji College of Pharmacy, Anantapur-515001, A. P, India

A B S T R A C T
A simple, economic, accurate UV method was developed for the estimation of Metaprolol in bulk and tablet dosage form. Water isused as a diluent to dissolve metaprolol. The drug mixture was sonicated for 3 mins for the enhanced solubility. The absorptions were observed at 223.0 nm, which was selected for the further analysis of metaprolol in bulk and its tablet dosage forms. The proposed method was validated according to ICH guidelines. The method showed high sensitivity with linearity range from 3 to 18 μg/mL (r²=0.999). The limit of detection (LOD) was found to be 0.29 μg/mL and the limit of quantization (LOQ) was determined as the lowest concentration was found to be 0.97 μg/mL. The reports expressed that the proposed method was found to be simple, precise, accurate and rapid for the estimation of metaprolol in bulk and tablet dosage form using UV spectroscopy.
Keywords: Metaprolol, water, UV spectroscopy, ICH guidelines.