A Review on Recent Approaches in Pharmacotherapy for management of Alzheimer’s Disease

A. Bharath kumar¹*, B. Kumar³, C. Gopinath¹, Sk. Karimulla^2
1Department of Pharmacy Practice, Annamacharya College of Pharmacy, Rajampet, A.P, India
²Department of Pharmacology, Dr. K.V. Subba Reddy Institute of Pharmacy, Kurnool, A. P, India
³Department of Pharmacy Practice, Ratnam institute of Pharmacy, Pidathapolur, Nellore, Andhra Pradesh, India

A B S T R A C T
It is a Neuro degenerative disease in which structural and functional ability of neuron is impaired. It is slowly starts with age progress. the alteration in the neuro transmitters levels in the brain. The neuro filbrillary tangles, neurotic plagues are responsible for the progression of disease. The alterations in the serotonergic systems raphae of the nucleus and cholinergic pathways in the brain is responsible for the loss of memory. The hyper-activation of glutamate levels in the brain is responsible for the progression of amnesia. The apolipoprotein E is responsible for the developing the disease. The oxidative stress, mitochondrial dysfunction affects the energy levels depletion in the brain affects the neuronal functions in the brain. it is caused by genetic involvement and environmental, life style factors plays a major role. The symptoms include aphasia, agnosia, apraxia, dementia, behavioural disturbances. It can diagnosed through MRI, CT scans, EEG examination were needed. The early diagnosis of the symptoms we can suppress the disease complications. The management of disease through medications and cognitive behavioural therapy to the patient.
Keywords: Memory. MRI, CT scan, neuro-filbrillary tangles, neurotic plagues.