A Review on Chronopharmaceutical Drug Delivery System

SK. Saddam Hussain*, S. Firoz, Ramya Sudha EM, K. Sarada, Ramesh. B, Jagadesh. k
Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, A.Rangampet, Tirupati, A.P

A B S T R A C T
Pulsatile Drug Delivery systems (PDDS) are basically time-controlled drug delivery systems in which the system controls the lag time independent of environmental factors like pH, enzymes, gastro-intestinal motility etc. These systems are designed according to the circadian rhythm of the body. The pulse has to be designed in such a way that a complete and rapid dug release should be achieved after the lag time. In recent years, pulsatile drug release systems are gaining importance in the clinical therapies includes asthma, peptic ulcer, cardiovascular diseases, arthritis, attention deficit syndrome in children, and hypercholesterolemia where night time dosing is required. Therefore Pulsatile drug delivery is one such systems that became trendy by delivering drug at the right time, right place and in right amounts, holds good promises of benefit to the patients suffering from chronic diseases.
Keywords: Cinnarizine, HPMC, Drug release kinetics, Ethyl cellulose, Diffusion exponent (n).