A Review on Alzheimer’s Disease

M.V. Sai Lalith kumar*, Y.N. Sujitha, S. Sudheer, K. Siva, Madhavi latha 
Nrayana Pharmacy College, Chinthareddypalem, Nellore, Andhra Pradesh, India

Abstract
Alzheimer’s disease, is also known in medical literature as Alzheimer disease, and is the most common form of dementia, which is not curable that as it progress and eventually death. Most of this disease is seen in the old age people of 65 above age, although less prevalent early onset Alzheimer’s can occur much earlier. 33 million people worldwide were afflicted with Alzheimer’s in 2009. Alzheimer’s is predicted to affect 1 in 85 people globally by 2050. It is a progressive degenerative disease that slowly destroys memory and thinking skills. The disease comes on gradually as two abnormal protein fragments called plaques and tangles accumulate in the brain and kill the brain cells. The disease starts from the hippocampus. The few hours or days ago the rest of this might may enters into different regions of the brain and destroys the cells and compromising functions of brain. In the early stages, the most common symptom is difficulty in remembering recent events, known as short term memory loss. When AD is suspected, the diagnosis is usually confirmed with tests that evaluate behaviour and thinking abilities, often followed by a brain scan. However, examination of brain tissue is required for a definitive diagnosis. The main symptom of the late stages of Alzheimer’s is personality and severe behaviour changes. The disease advances, gradually body functions are lost, ultimately leading to death. On average, the life expectancy following diagnosis is approximately seven years.[9] Fewer than 3% of individuals live more than 14 years after diagnosis. The Alzheimer’s disease is a neurodegenerative disorder. In developed countries, AD is one of the most costly diseases to society.
Keywords: Plaques, Tangels, Alzheimer’s Disease, Hippocampus