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About author:
E. Anka Rao*, B. Dayasagar, M. Madan Mohan Reddy
P. Ram Babu, D. Mahidhar Reddy, K. Jyothirmai, P.V. Anudeep
Narayana Pharmacy College, Nellore, AP, India
*E-mail : ankarao25@yahoo.co.in
ABSTRACT:
An excipient is generally a pharmacologically inactive substance used as a carrier for the active ingredients of a medication. In many cases, an “active” substance (such as acetylsalicylic acid) may not be easily administered and absorbed by the human body; in such cases the substance in question may be dissolved into or mixed with an excipient. Excipients are also sometimes used to bulk up formulations that contain very potent active ingredients, to allow for convenient and accurate dosage. In addition to their use in the single-dosage quantity, excipients can be used in the manufacturing process to aid in the handling of the active substance concerned. Depending on the route of administration, and form of medication, different excipients may be used. For oral administration tablets and capsules are used. Suppositories are used for rectal administration. Once an active ingredient has been purified, it cannot stay in purified form for long. In many cases it will denature, fall out of solution, or stick to the sides of the container. To stabilize the active ingredient, excipients are added, ensuring that the active ingredient stays “active”, and, just as importantly, stable for a sufficiently long period of time that the shelf-life of the product makes it competitive with other products.
Key Words : Excipient, Blinding agent, Acetylsalicylic acid, stabilize
