Levamisole as an Immunomodulatory Agent for PPR Vaccinated Goats

Author Details
M Das¹, DP Isore¹, I Samanta¹, SK Mukhopadhayay²*, S Ganguly³*, S Pal^1 
1Department of Veterinary Microbiology, ²Department of Veterinary Pathology, Faculty of Veterinary & Animal Sciences, 37, K.B. Sarani, Belgachia, Kolkata – 700 037, West Bengal, India
³AICRP-PHT (ICAR), Department of Fish Processing Technology, Faculty of Fishery Sciences,
University of Animal and Fishery Sciences, 5, Budherhat Road, P.O. Panchasayar, Chakgaria, Kolkata – 700 094, West Bengal, India

Abstract
In the present study, levamisole was used as an immunomodulator with PPR cell culture vaccine (live attenuated type). Elevated antibody titer was obtained when levamisole was used prior to the PPR vaccination in treatment groups. Due to vaccination there was also increase in the immunity which can be denoted from 14 day to 30 day. There was gradually an increase in the immune response because after vaccination the antibody producing cells activity increased. So, in the serum the vaccine titer was elevated, but after some time when the activity of antibody producing cells decreased, there was also a decline in immune status. Levamisole is a non-specific immunostimulator which can increase both the humoral and cellular immunity. 12 goats aged 6 months-1 year old were considered in the present investigation to assess the effect of levamisole as an immunomodulator on PPR vaccinated animals. Four animals were considered in each group with one group as control. In the present study, when the vaccine was administered with levamisole then the activity of immune effector cells also increased.
Keywords: Goats, Immunomodulator, PPR, Vaccine