A Novel strategies of progesterone: To improving the solid-state of dosage forms by co-crystallization process

Dharani. Muthukuru*, G. Sujatha, Dr. Y. Prapurna Chandra
Ratnam Institute of Pharmacy, Pidathapolur (V&P), Muthukur (M), SPSR Nellore District – 524 346

Abstract
Progesterone injection is oily because of its poor solubility. It is necessary to develop new dosage forms or delivery methods for Progesterone with nitrogen heterocyclic compounds (2,6-diaminopyridine, isonicotinamide, 4-aminopyridine, aminopyrazine, picolinamide and pyrazinamide) have been designed and prepared by ethyl acetate-assisted grinding, of which four co-crystals (2,6-diaminopyridine, isonicotinamide, 4-aminopyridine and aminopyrazine) had single crystal in stoichiometry. Metadynamics- generic crossing was used to optimize various Custer structures to explain the reason the other two o-crystals.  Shear assisted sono-crystallization is novel techniques for co-crystallization and also used in particle engineering in detailed list out in this article. According to the novel crystal engineering strategies, the co-formers of 2-chloro-4-nitroaniline (CNA), 2,5-dihydroxy benzoic acid (DHB), 4,4”-biphenol (DOD) were prepared by progesterone. The co-crystals were obtained by slow evaporation method and grinding ball mill. These co-crystal were confirmed by X-ray diffraction. IR spectroscopy, powder X-ray diffraction etc, the PROG-CNA co-crystal had the faster rates and highest concentrations as compared to other co-crystal in dissolution experiments. All co-crystals more stable in water and progesterone-pyrazinamide co-crystals featured the best water solubility performance with am approximately. Six- fold increase over free progesterone. This article provides an effective route for designing and manufacturing novel solid states of progesterone.
Keywords: progesterone, pharmaceutical co-crystals, crystal engineering, nitrogen heterocyclic compounds