To Develop Sustained Release Mucoadhesive Tablets of Atorvastatin by Using Hydrophilic Polymers

E. Vijay Kumar*, Y.Pavithra¹, Y. Sreelekha², Y.Sunitha³, V. Praveen Kumar⁴
*Associate Professor, Srinivasa Institute of Pharmaceutical Sciences, Proddatur, A.P, India
^1,2,3,4Srinivasa Institute of Pharmaceutical Sciences, Proddatur, A.P, India

A b s t r a c t
Atorvastatin is a choice of drug for anti-hyper lipidemic the concept of formulating and evaluating matrix tablets that it offers a suitable and practical approach in serving desired objective of prolonged action for anti-hyper lipidemic activity exhibiting good absorption of the drug of the different batches of formulations were prepared increasing the concentrations of HPMC K 15 M, Gum Karaya and Guar gum. A controlled release Gastro retentive blend formulated were evaluated for Bulk density, tapped density, Angle of repose, Compressibility index, carr’s index and in-vitro drug release studies.
Keywords: Compressibility index, in-vitro drug release, carr’s index, anti-hyper lipidemic