Preparation and Evaluation of Solid dispersions of Febuxostat

Radhika P*, Venkata Ramana M¹
*Moonray College of Pharmacy, Hyderabad, Telangana.
¹Azad College of Pharmacy, Hyderabad, Telangana

A B S T R A C T
Among the various methods of enhancement of dissolution rate and oral bioavailability, cyclodextrin complexation and solid dispersion technologies were found to be very successful with Febuxostat. As such their oral bioavailability and efficacy are severely limited by their poor aqueous solubility and dissolution. They need enhancement in solubility and dissolution rate for improving their oral bioavailability. Cyclodextrin complexation and solid dispersion technologies were tried for improving the dissolution rate and bioavailability of the selected drugs. Complexation of the selected drugs with β and hydroxy propyl β-cyclodextrins, the effect of cyclodextrins on the solubility, dissolution rate, and bioavailability of the selected drug (Febuxostat) and the feasibility of formulating the CD complexes into compressed tablets were investigated.
Keywords: Febuxostat, β and hydroxy propyl β-cyclodextrins, Bioavailability, Dissolution