Anti-diabetic activity of a polyherbal preparation in Alloxan-induced diabetic rats

S. Nivedhitha¹, K. Sravani²*, N. Shivakrishna³, K. Navajyothi^3
1Department of Pharmacognosy, Ratnam Institute of Pharmacy, Pidathapolur, Nellore-524346.
²Department of Pharmacology, Ratnam Institute of Pharmacy, Pidathapolur, Nellore-524346.
³Department of Pharmacology, Nalanda College of Pharmacy, Nalgonda, Telangana

A B S T R A C T
The present research work mainly focused on evaluation of anti-diabetic activity in poly herbal preparation in alloxan –induced rats. In this study using polyherbal preparations are Momordica charantia, Eugenia jambolana and Ocimum sanctum, it was prepared by in the ratio of 1:1:1. These herbal plants also exhibit the Antibacterial Activity, Antiviral activity, Anti-HIV activity, Antiherpes activity, Anti-poliovirus activity and Anticancer activity.Momordica charantia (fruits), Eugenia jambolana (seeds), Ocimum sanctum (leaves), Allium cepa (juice) have been used traditionally to alleviate increased blood glucose level.In the present study, we have measured the potential of Poly Herbal Preparation extract to inhibit lipid peroxidation in rat liver homogenate, induced by the FeCl₂–H₂O₂ system.Poly herbal xtracts having both hypoglycemic and antioxidative properties would be useful antidiabetic agents. Anti-diabetic activity in polyherbals were compard to the alloxan-induced diabetic rats. It is suggested that is helpful in maintaining the hyperglycaemia as well as the complication which are frequently seen in diabetic patients.
Keywords: Anti diabetic activity, Poly herbal, Alloxan, Momordica charantia, Eugenia jambolana and Ocimum sanctum