Development and In-Vitro Evaluation of Resperidone Delayed Release Tablets

A. Srinivas¹, Gampa Vijaya Kumar*², Vijay Prakash³, K. Someshwar^4
1CVM college of Pharmacy, Karimnagar, Telangana, India
²Professor & Principal, CVM college of Pharmacy, Karimnagar, Telangana, India
³Assistant professor, CVM college of Pharmacy, Karimnagar, Telangana, India
⁴Managers, Formulation R&D, KP Labs (A Division of KDPL), Kothapet, Hyderabad, Telangana, India

A B S T R A C T
The aim of the present study was to develop Delayed release formulation of Resperidone to maintain constant therapeutic levels of the drug for over 10 hrs. Various natural polymers such as Guar gum, Xanthan gum and Chitosan were employed as polymers. Resperidone dose was fixed as 10 mg. Total weight of the tablet was considered as 100 mg. Polymers were used in the concentration of 20 and 40 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F3) showed better and desired drug release pattern i.e., 97.65 % in 10 hours. It followed zero order release kinetics mechanism.
Keywords: Resperidone, Guar gum, Chitosan, Xanthan gum and Delayed release tablets.