Formulation and Evaluation of Bilayer Tablets of Pioglitazone and Glibenclamide

Jeripiti Usha, Venugopalaiah P*, Gnanaprakash K, Gobinath M
Department of Pharmaceutics, Ratnam Institute of Pharmacy, Pidathapolur, Muthukur, Nellore-524346, A.P, India

A B S T R A C T
An attempt was made to formulate the bilayer dosages form containing Pioglitazone HCl as immediate release layer and Glibenclamide as sustained release layer, for the management of Type II Diabetes Mellitus. The individual layers were prepared for the estimation of the effect of polymers like HPMC, PVPK 30, Lactose used and they were optimized individually. Finally, selected individual formulations were subjected to the formulation and compressed as Bilayer Tablets. The prepared tablets were characterized using various tablet parameters and the data was brought forth. All the formulations showed maximum release of about 97.52 % for the immediate release layer and 91.18 % release of the sustained release layer (F9). The stability tests were conducted on ‘F9’ and the formulation was analyzed for its moisture content and dissolution profile. The results showed that the color and gross nature of tablets was slightly changed for batch-2 which is kept at 60°C/80%RH. Changes were not seen in batch-1&2 which are kept at 40°C/70%RH. The percentag樂威壯
e of moisture content of ‘F9’ showed high values when the tablets are kept outside the container at room temperature and relative humidity.
Keywords: Tablets, Diabetes Mellitus, Pioglitazone HCl, Glibenclamide, Immediate