Pharmacological Evalution of Anti-Inflammatory activity of methanolic extract of cordial subcordata.lam

C. Madhavi Latha*^1,2_, K. Bhaskar Reddy^3
1Research Scholar, Pacific University of Higher Education and Research University, Udaipur, Rajastan, India.
²Department of Pharmacology, Jagan’s College of Pharmacy, Nellore, Andhra Pradesh, India.
³Department of Pharmaceutics, Sri Venkateswara College of Pharmacy, RVS Nagar, Chittoor, India.

A B S T R A C T
The main object of the present work is to find out good pharmacological activities in herbal source with their preliminary phytochemical study, and also it is aimed to investigate of methanol extract of whole plant cordia subcordata. The carrageenan induced hind paw edema, cotton pellet induced granuloma model was used to srudy in-vivo anti inflammatory activity and membrane stabilization test, inhibition of albumin denaturation models for in-vitro anti-inflammatory activity of methanolic extract of whole plant. Indomethacin (4mg/kg)Was used as standard drug for carrageenan induced paw oedema model, diclofenac sodium (5mg/kg) Was used as standard drug for cotton pellet induced granuloma  model, aspirin (200 µg/ml) was used as standard drug for membrane stabilization, inhibition of albumin denaturation  model. Acute edema in the left hind paw of the animal was induced by subplantar injection of 0.1ml (1%) carrageenan suspension in normal saline. The methanolic extract of the plant of cordial subcordata very significantly (p<0.001) reduced the paw edema in carrageenan treated rats. The effect was maximum at 3 hr after carrageenan injection. The significant suppression of inflammation during the whole experimental period indicates the long duration action of the methanolic extract of the plant.
Keywords: Perindopril, Synthetic polymers and sustained release tablets.