Formulation and Evaluation of Niacin Extended Release Tablets

Dr. R .Srinivasan¹, Sk. Shakir Ahmad*¹, D. SK. Sarma¹, D. Rajesh Kumar¹, Dr. K. Ravi Kumar², A. Anil Kumar^1
1Siddhartha Institute of Pharmaceutical Sciences, Jonnalagadda, Narsaraopet, Guntur, A.P, India
²Assosciate Professor, Hindu college of Pharmacy, Guntur, Andhra Pradesh, India

A B S T R A C T
The objective of the present work was to develop extended release tablets of Niacin using various grades of Eudragit polymers and Film forming agents like Surelease, Kollicoat SR 30D, Eudragit RL 100 either alone or in combination. Tablets were prepared by Wet Granulation method. The different excipients were tested for their compatibility with the drug by using FTIR Studies which revealed that there was no interaction. The Pre-compression parameters such as bulk density, tapped density, Compressibility index and hausner ratio were analyzed for the prepared tablet blend were found to be satisfactory. The Post-compression parameters such as thickness, hardness, friability, weight variation, drug content uniformity were evaluated for core tablets and they were within the pharmacopoeial limits. The in-vitro drug release studies were performed in USP Apparatus I (Basket). Among the formulations F11E showed drug release for 24 hrs with cumulative percentage of 98.9 similar to that of Innovator. The kinetic treatment showed that the optimized formulation followed Korsemeyer-peppas with release exponent (n) 0.759. The results indicated that the selected formulation was stable during stability studies. The formulation F11E showed diffusion coupled with erosion mechanism of drug release.
Keywords: Extended release, Eudragit polymers, Wet Granulation, Korsemeyer-peppas, diffusion, Erosion.