Validation of HPLC Method of Aceclofenac and Rabeprazole Sodiumin Aceclofenac Sustained Release and Enteric Coatedrabeprazole Sodium Capsules

Kalpana Patankar-Jain¹, Parag Gadkari², Pushkar Pradhan^3
1Department of Chemistry, B. N. N. College, Bhiwandi
²Inventia Healthcare Pvt. Ltd., Thane
³Department of Chemistry, Ramnarain Ruia College, Mumbai

A B S T R A C T
The current research paper gives method validation report for the simultaneous quantification of Aceclofenac Sustained Release 200mg and Enteric Coated Rabeprazole 20mg capsules. The method involved an isocratic system of Phosphate buffer pH 7.8 and methanol. The column used is Hypersil BDS C18 column with dimentions (250 mm * 4.6 * 5 u). The compounds gave a good UV response at 280 nm, hence the detection wavelength. The developed method is simple, precise, robust and stands validated as per ICH guidelines.
Keywords: Hypersil BDS C18, methanol, RP-HPLC, Validation, Coatedrabeprazole Sodium Capsules