Synthesis, Spectroscopic Characterization, Biological Screening, and DNA Nuclease Activity of Schiff base Metal Complexes Derived from o-phenylenediamine

ABOUT AUTHOR
P. Maheswaran, E. Akila*, M. Usharani, R. Rajavel
Deparment of Chemistry, Periyar University, Salem-636 011, Tamil Nadu, India.
*E-mail: akilachemphd@gmail.com

Abstract
Novel series of mononuclear Schiff base Cu(II), Co(II), Ni(II) and Mn(II) complexes have been synthesized with Schiff base derived from 2- thiophenecarboxaldehyde, o- phenylenediamine, furfuraldehyde and 2,2′ bipyridyl. The chelation of the metal complexes has been proposed in the light of analytical, spectral (IR, UV, ¹H NMR, ESR) and magnetic studies. These data reveals that the Schiff base complexes exhibit the octahedral geometry. The Schiff base and their metal complexes have been screened for their antibacterial activities. The complexes show significant growth inhibitory activity against the bacteria like Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Klebsilla pneumonia than the free ligands. The nucleolytic cleavage activities of the complexes were assayed on pUC18 plasmid DNA using gel electrophoresis in the presence of H₂O₂ and the complexes show promising nuclease activity.
Keywords: 2- thiophenecarboxaldehyde, nuclease activity, 2, 2′ bipyridyl