Synthesis, Characterization and Evaluation of Antimicrobial profile of 4-Thiazolidinone derivatives

Asish Bhaumik*¹, M. Upender Kumar¹, M. Sucharitha¹, Dr. P. Panneerselvam², Sunil Kumar Sing^2 
1Dept. of Pharmaceutical Chemistry, Teja College of Pharmacy, Kodad, Nalgonda-508206, Telangana, India
²Dept. of Pharmaceutical Chemistry, C.L. Baid Metha College of Pharmacy, Jyothinagar, Thoraipakkam, Chennai-600097, India.

Abstract
The objective of the present work was the synthesis of N-[2-(4-substituted phenyl)-4-oxo-1,3-thiazolidine-3-yl]-2-(naphthalene-2-yloxy)acetamide and evaluation of in-vitro antimicrobial  activity. Based on this a new series of compound had been planned to synthesize by reacting β-naphthol, ethyl chloroacetate, hydrazine monohydrate, ethyl alcohol and various aromatic aldehydes in presence of anhydrous potassium carbonate The synthesized compounds were characterized by IR, NMR, and Mass spectroscopy. The in-vitro antimicrobial profile of newly synthesized compounds were carried out by using agar diffusion method using bacterial cultures of Staphylococcus aureus (ATCC 9144) and Escherichia coli (ATCC 25922) and fungal culture of Aspergillus niger (ATCC 9029). By observing it was found that most of the synthesized compounds executed moderate to good antimicrobial activity against the tested micro-organisms. The most of the synthesized compounds were active against all the tested micro-organisms for antimicrobial activity with an MIC range of 15-40µg/ml. The MIC values for the synthesized  compounds  were found to be A2 (MIC of 15 µg / ml), A10 (MIC of 16 µg / ml), and A5 (MIC of  17) against Staphylococcus aureus (ATCC 9144) and A2 (MIC of 16 µg / ml), A10 (MIC of 19 µg / ml), and A5 (MIC of  18) against Escherichia coli (ATCC 25922) and A1 (MIC of 16 µg / ml), A3 (MIC of 19 µg / ml), and A5 MIC of 18 µg / ml) against Aspergillus niger (ATCC9029).
Keywords: Thiazolidinone, Antimicrobial, IR, NMR, MIC