Synthesis, Characterization and Biological Evaluation of 2-styrylchromone Derivatives

SK. Asma Thunnisa*, Bodapati Raju
Department of Pharmaceutical Chemistry, Vikas College of Pharmacy, Visannapeta, Krishna-521215(Dt), A.P, India

A B S T R A C T
In this present study of the Design, Synthesis and molecular docking studies of 2-styrylchromone derivatives as novel antioxidant agents was considered chromone as basic fundamental pharmacophore in order to show antioxidant properties. We have performed molecular docking studies of synthesized compounds to check the ligand interactions with target protein. In addition, ADMET studies and molecular simulations studies also performed to know the toxicity and other parameters of synthesized molecules. Finally, through molecular modelling studies it is concluded that the synthesized molecules follows Lipinski rule of five.
Keywords: 2-styrylchromone, Antioxidant, Molecular docking, Molecular modelling, Lipinski rule