Synthesis and In-silico Studies of Novel Methylene Bridge Derivatives of Anthracene

G.T. Roopesh*, N. Sreelekha, P. Susmitha, P. Pallavi, M. Maniteja, B. Swapna
Balaji college of pharmacy, Dept. of Pharmaceutical Chemistry Ananthapuramu, A.P, India.

A B S T R A C T
The present work was aimed to Synthesise and carryout Insilico studies of Methylene Bridge Derivatives of anthracene. Anthracene is mainly converted to anthraquinone, a precursor to dyes. The anthracene chromophore plays a prominent role in the development of organic photochemistry. Anthracene derivatives have been extensively investigated in many fields, e.g., material chemistry, thermo chromic or photo chromic chemistry and organic light-emitting devices. Moreover, anthracenes have been used in optical, electronic and magnetic switches. In biological systems, anthracene skeletal compounds are also useful for probing DNA cleavage [5]. In medicinal field the anthracene derivatives act as good anti-cancerous drugs and they are carcinogenic to many living beings. Molecular descriptors, such as log P (partition coefficient), molecular weight (MW), the acceptors and donors for hydrogen bonding in a molecule and topological polar surface area (TPSA) were calculated using the online software (http://www.molinspiration.com/). These descriptors are strongly associated with membrane permeability and oral bioavailability.
Keywords: Synthesis, In-silico, Bioactivity, Methylene bridge derivatives.