Synthesis and Biological Evaluation of Some novel Schiff’s bases of Veratraldehyde

Author Details
Naga Prashant. K* and Anupama. S
Department of Pharmaceutical Chemistry, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopet, Guntur, Andhra Pradesh, India.

Abstract
The need of anthelmintic drugs in the market is increasing day to day. The present study was designed to synthesize various veratraldehyde derivatives. The synthesized compounds were evaluated for anthelmintic activity. Streptomycin was used as standard drug for evaluation. The several veratraldehyde derivatives were synthesized on basis of two classes. Class-I derivatives were synthesized by reacting free aldehyde group of veratraldehyde with hydrazines and their halides. Class-II derivatives were synthesized by reacting free aldehyde group of nitro veratraldehyde with various hydrazines. Class-II compounds showed better inhibitory zone when compared with other classes of compounds.
Keywords: Semi-synthetic, Schiff’s bases, Veratraldehyde, nitration, antimicrobial.