Synthesis and Biological Evaluation of Some Novel Aryl Substituted thiazolyl-4-thiazolidinone fused Pyrimidines as Potent Anti-Microbial and Anti-Inflammatory Agents

Iram Khan^a and Bhawani Singh^b*
^aDepartment of Chemistry, Banasthali Vidyapith, Banasthali (Rajasthan)-304022, India
^bDepartment of Pure & Applied Chemistry, University of Kota, Kota (Rajasthan)-324005, India

A B S T R A C T
An innovative series of aryl substituted thiazolyl 4-thiazolidino pyrimidines has been synthesized by the condensation of 5-dimethylaminomethylene-2-(4-phenyl-thiazol-2-ylimino)-thiazolidin-4-one with urea, thiourea and guanidine and evaluated for their anti-microbial and anti-inflammatory activities. Three compounds were used for screening of anti-bacterial activity as well as anti-fungal activitity and one compound screened for anti-inflammatoty activity.
Keywords: 5-Dimethylaminomethylene-2-(4-phenyl-thiazol-2-ylimino)-thiazolidin-4-one, thiazolidino-pyrimidines, Anti-Inflammatory Activity, anti-microbial activity.