Study of induced inflammation effect on motor activities and coordination in wistar rats.

Olorunfemi O.J., Okosiemiama S.C., Okopido I.S, Okpe E.
Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Choba, Port Harcourt, Nigeria.

ABSTRACT
This study was designed to investigate the effect of egg albumin extract on motor activities and coordination using 20 adult wistar rats, they were divided into four groups, each consisting of five animals in each compartment. The rats were all induced with inflammation using egg albumin. Group 1 which was the control not subjected to any inflammation. Group 2 were given 0.3ml of albumin on their forelimb paws intradermally, a known extract that causes inflammation. Group 3 were given 0.3ml of albumin on their hind limbs paws intradermally. Group 4 were given 0.3ml of albumin on their forelimbs paws intradermally and after four hours, 1ml of indomethacin was given intraperitoneally (A non-steroidal anti-inflammatory drug). The research work as an acute experiment lasted for 14 days. After induction of egg albumin administration of same dose, there was gradual inhibition of motor activities and coordination. The data derived shows that induced inflammation using egg albumin has influence on the motor activities and coordination when compared to the control. In membrane stability study with aspirin (indomethacin) shows about 91% effectiveness in stability.
Keywords: inflammation, indomethacin, motor activities, intradermal, intraperitoneal.