Study of Analgesic Activity of Ethyl Acetate Extract of Cleome Gynandra

Radhika C¹, Saravanakumar K², Nagaveni P³, Nethra Vani G⁴, Sravanthi P^2
1Mahathi College of Pharmacy, Madanapalle-517319, Chittoor, Andhra Pradesh, India
²Sree Vidyanikethan College of Pharmacy, A. Rangampet, Tirupati-517102, Chittoor, A.P, India.
³Gokula Krishna College of Pharmacy, Sullurpet 524121, SPSR Nellore, Andhra Pradesh, India.
⁴Oil Technological and Pharmaceutical Research Institute, JNTUA-Ananthapuramu, Andhra Pradesh, India.

A B S T R A C T
Cleome gynandra is an abundantly available species and grows as a weed in common barren land and in crop fields throughout India. This plant is having Immunomodulator, Antioxidant, Ant carcinogenic, Analgesic properties etc. The ethyl acetate extract was obtained by simple maceration method and the analgesic activity of whole plant of cleome gynandra (75, 100, 125 mg/Kg was analyzed by writhing method using acetic acid as analgesic inducing agent. Diclofenac sodium was (20mg/Kg) is used as a standard and mice are used as animal models. Results shown that the whole plant extract has flavonoids, tannins, saponins etc. and the group of animals were injected 75, 100, 125 mg/Kg intraperitonially with plant extract has shown 80.87 % , 90.59, 91.73, and 93.84 % inhibition of wriths respectively than the standard 93.84 % and control groups. So, it can be concluded that the ethyl acetate extract of Cleome gynandra has the analgesic activity.
Keywords: Cleome gynandra, Analgesic, Algesia, Writhing method, Saponins, Alkaloids.