Spectrophotometric Method for the Estimation of Nicorandil in Tablet Dosage form

Kumar Raja Jayavarapu*, Suresh.V. Chennupati, Gaddala Mounika, Bejawada Saikrishna and Tatikonda. Usha
Department of Pharmaceutical Analysis, Mother Teresa Pharmacy College, Sathupally, Khammam -507303, India.

A B S T R A C T
A simple and sensitive spectrophotometric method for the determination of Nicorandil in tablet dosage form was described. From the solubility data 0.1 N NaOH was used as solvent and shows absorption maximum at 260 nm. The Beer’s Law range is 05–25 µg/ml. The linear regression for method found to be 0.99998. When tablet dosage forms where analyzed, the results obtained by the proposed methods are in good agreement with the labelled amount and the results were validated statistically.
Keywords: Nicorandil, UV spectroscopy, tablet dosage form, statistical validation