Solid Dispersion-A Strategy for Improving the Solubility of Lipophilic Drugs

Krishna Moorthy S.B,*¹ Sandeep. J², Rajalakshmi.R¹, Rubiya SK¹, Saddam hussain. SK^1  
1Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, A. Rangampet, Tirupathi, Andhra Pradesh, India. 517102.
²Department of Pharmaceutics, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupathi, Andhra Pradesh, India. 517503.

Abstract
Improving oral bioavailability of drugs those given as solid dosage forms remains a challenge for the formulation scientists due to solubility problems. The dissolution rate could be the rate-limiting process in the absorption of a drug from a solid dosage form of relatively insoluble drugs. Therefore increase in dissolution of poorly soluble drugs by solid dispersion technique presents a challenge to the formulation scientists. Solid dispersion techniques have attracted considerable interest of improving the dissolution rate of highly lipophilic drugs thereby improving their bioavailability by reducing drug particle size, improving wettability and forming amorphous particles. The term solid dispersion refers to a group of solid products consisting of at least two different components, generally a hydrophilic inert carrier or matrix and a hydrophobic drug. This review discusses the recent advances in the field of solid dispersion technology.
Keywords: Solid dispersions, solubility, dissolution rate, bioavailability, particle size.