Potential Antimicrobial Therapeutic Applications of Coumarine Derivatives: A Review

T. Yunus Pasha*, Shankar M, Vidya A.D
Department of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, Adhichunchanagi University, B. G Nagar-571448, Nagamangala Taluk, Mandya, Karnataka.

A  B  S  T  R A C T
Coumarin is a fused heterocyclic compound consists of benzene and pyrone ring containing oxygen and its derivatives are of wide awareness because of their numerous biological activity and clinical applications coumarins are regarded as a promising class of bioactive heterocyclic compounds that shows of biological activities like anti-microbial, anti-viral, anti-diabetic, anti-cancer activity, anti-oxidant, anti-parasitic, antihelmintic, anti-proliferative, anti-convulsant, anti-inflammatory, and anti-hypertensive activities. The objectives this review is to focus on important coumarine analogues with good antimicrobial activity, hiliting their mechanism of action and structural activity relashionship on selected receptors helps for designing and synthesis of novel coumarin derivatives for the better antimicrobial activity.
Keywords: Coumarin, Anti-microbial activity, Pyrimidine