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Author Details
Dinesh Chandra*1, Rakesh Singh1, Shaundarya Kumar1, Usha Rai1, Vijay Kumar Singh1, Vaibhav Prakash Srivastava2
1Kamala Nehru Institute of Management & Technology, Sultanpur, U.P, India
2Vishveshwarya Institute of Medical Sciences, G. B. Nagar, U.P, India
Abstract
The aim of the present study is to formulate Solid Dispersion containing Artesunate in different drug to polymer ratio by Solvent Evaporation Method to improve solubility and dissolution rate of poorly water soluble Artesunate by complexation with PEG 6000. The drug carrier interactions in the solid state were investigated using saturated solubility studies, FTIR spectroscopy, X-ray diffraction and differential scanning calorimeter. The developed formulation overcome and alleviates the drawbacks and limitations of Artesunate sustained release formulations and could possibility be advantageous in terms of increased bioavailability of Artesunate. The drug carrier interactions in the solid state were investigated using saturated solubility studies, FTIR spectroscopy, X-ray diffraction and differential scanning calorimeter. The developed formulation overcome and alleviates the drawbacks and limitations of Artesunate sustained release formulations and could possibility be advantageous in terms of increased bioavailability of Artesunate. The solubility issues complicating the delivery of these new drugs also affect the delivery of many existing drugs. The ability to deliver poorly soluble drugs will grow in significance in the coming years as NCEs are relied upon for a larger share of the revenue within the pharmaceutical market by innovator companies. Similarly, generic drug manufacturers will need to employ economically efficient methods of delivery as more low solubility drugs go off patent, in order to maintain a competitive edge and sufficiently compete as profit margins shrink in this price-sensitive industry. Relative to highly soluble compounds, low drug solubility often manifests itself in a host of in vivo consequences, including decreased bioavailability, increased chance of food effect, more frequent incomplete release from the dosage form and higher inter patient variability.
Keywords: Artesunate, Solid dispersion. Solubility enhancement, PEG 6000
