Optimization and Evaluation of Immediate Release Tablet in combination of EZETIMIBE and SIMVASTATIN drugs

ABOUT AUTHOR
Nutan  Kumari*, Dr. B. Srivasatva, Ajay Kumar Tiwari, Ms. Renu  Kalyanwat
School of Pharmaceutical Sciences
Jaipur National University
E-mail: nutan216@gmail.com

ABSTRACT
hypercholesterolemia disease treatment with HMG-CoA reductase inhibitors has been very successful.The purpose of this study was to assess the efficacy and safety of ezetimibe administered with simvastatin in patients with primary hypercholesterolemia. This paper will examine two of the more popular secondary agents, ezetimibe and Simvastatin , and describe their research data and potential for usefulness in further reducing hypercholesterolemia. This study was performed with the intention of finding the effect of preparation methods on the solubility and dissolution of Simvastatin by using the surfactant. The complexes were prepared by wet granulationation and Spray drying techniques. The formulations were evaluated for phase solubility and in-vitro release study.The formulations were also subjected for physicochemical characterizations.

Key words: Propyl gallate, Butylated Hydroxy Anisole, Polysorbate 80, Sodium Lauryl sulphate,Ezetimibe, Simvastatin