Nutritional Regimen of Synbiotics in Managerial Dietetic Contrive for Healthy Lifestyle

Bina Rani¹, Upma Singh², Sangeeta Agarwal³, Rita Singh Mazumdar⁴, Raaz K Maheshwari*^5
1Department of Engineering Chemistry & Environmental Engineering, Poornima College of Engineering, Jaipur, Rajasthan India
²Department of Applied Chemistry, School of Vocational Studies & Applied Sciences, Gautam Buddha University, Greater Noida, UP, India
³Department of Chemistry, SSV PG College, Hapur, Ghaziabad, UP
⁴Department of Biotechnology, Sharda University, Greater Noida, UP, India
⁵Department of Chemistry, SBRM Govt. PG College Nagaur, Rajasthan, India

A B S T R A C T
The benefits of probiotics & prebiotics are supported by all-embracing research. Prebiotics have been extensively researched since their documentations. This research has typically been done at research-oriented universities, often in Europe where awareness of prebiotics is uppermost. Probiotics are already in use for the wide array of beneficial effects that they can produce particularly with respect to the diseased condition. The potential areas which the use of synbiotics can target include the alteration in the colonic microbiome content, changes in insulinemia, fatty acid metabolism modifications, improvements in the absorption and bioavailability of the dietary minerals like Ca, Zn & Fe. The exerted negative influence on colon cancer is another area of potential future research. Besides, the breakdown of inulin like polysaccharides by the probiotics results in the synthesis of a number of low energy sugar molecules which can also be quite interesting from the point of food product development. Such evidences have come up in experiments to assess the combined role of inulin and bifidobacteria as anticancer agents. Insufficient or at most preliminary evidence exists with respect to cancer prevention, a so-called hypocholesterolemic effect, improvement of the mouth flora and caries prevention or prevention or therapy of ischemic heart diseases or amelioration of autoimmune diseases (e.g. arthritis). A prebiotic is “a selectively fermented ingredient that allows specific changes, both in the composition and/or activity in the gastrointestinal microflora that confers benefits upon host well being and health”, whereas synergistic combinations of pro- and prebiotics are called synbiotics. Today, only bifidogenic, non-digestible oligosaccharides (particularly inulin, its hydrolysis product oligofructose, and (trans) galactooligosaccharides), fulfill all the criteria for prebiotic classification. They are dietary fibers with a well-established positive impact on the intestinal microflora. Other health effects of prebiotics (prevention of diarrhoea or obstipation, modulation of the metabolism of the intestinal flora, cancer prevention, positive effects on lipid metabolism, stimulation of mineral adsorption and immunomodulatory properties) are indirect, i.e. mediated by the intestinal microflora, and therefore less-well proven. In the last years, successful attempts have been reported to make infant formula more breast milk-like by the addition of fructo- and (primarily) galactooligosaccharides.
Keywords: Super duos natural products, probiotics, prebiotics, bifidobacteria, microflora, oligofructose