Mannich Bases and Their Biological Activity

Priyadharshini S*, J. Amutha Iswarya Devi and N. Venkateshan
Department of Pharmaceutical Chemistry, Arulmigu Kalasalingam College of  Pharmacy, Anand Nagar, Krishnankoil-626126, Srivilliputtur (via) Tamil Nadu, India

A B S T R A C T
Mannich bases are the important pharmacophores for the development of various new and potent drugs with high pharmacological value. The mannich base is also known as β-amino carbonyl compound, is obtained by the amino alkylation of acidic proton next to a carbonyl functional group by formaldehyde and a primary amine/secondary amine or ammonia. Mannich bases are highly reactive and can be easily converted into other products. Mannich bases have various pharmacological actions such as analgesic, anti-convulsant, anti-bacterial, anti-fungal, anti-filarial, anti-inflammatory, anthelmintic, anti-tubercular and anti-cancer properties. 
Keywords: Amines,Carbonyl functional group, Mannich base, Pharmacological activity.