Green Synthesis of Itaconic Acids from Stobbe Condensation Method

Yadav Hanuman Singh¹, Gadegone Sunita² and Pande Hemant^{3
1, 3}Dr. Ira Nimdeokar Research Center for Chemistry, Hislop College, Nagpur 440001, India
²Department of Chemistry, Kamla Nehru Mahavidyalaya, Nagpur 440009, India

A B S T R A C T
One pot synthesis of acid esters by Stobbe condensation of alkylidene / arylidene succinates and aldehydes or ketones, their subsequent hydrolysis to diacids were reported. The Stobbe condensation of various aromatic aldehydes or ketones with dimethyl succinate gives different types of diacids [2a,(E)-2-benziledenesuccinicacid)],[2b,(Z)-2-(1-phenylethylidene)succinic acid], [2c , 2-(propan-2-ylidene) succinic acid)], [2d , 2-(diphenylmethylene) succinic acid)], [2e ,(Z) -2-(Furan-2-ylmethylene) succinic acid)] through green approach. The improved yields of Itaconic acid were observed by the green approach method as compared with other classical methods employed so far.
Keywords: Green synthesis, Stobbe condensation, aryl aldehydes & ketones, Itaconic acid and their products.