Formulation and In-vitro Characterization of Clobazam Fast Dissolving Tablets by Solid Dispersion Technique

K. Jyosthsna, K. Umasanker
Krishna Teja Pharmacy College, Tirupathi, Andhra Pradesh, India

ABSTRACT
Clobazam belongs to the 1, 5-benzodiazepine class of drugs and is expected to have a better side-effect profile compared to older 1,4-benzodiazepines.  It is a BCS class II drug having higher half-life. To improve the biological performance of Clobazam solid dispersion with oral disintegrating tablet was formulated by using Povidone, Mannitol. Solid dispersions of Clobazam were prepared with different carriers in different ratios of drug and carrier (1:1, 1:2 and 1:3). Results of prepared solid dispersions of Clobazam by solvent evaporation method were discussed which includes solubility, melting point determination, drug content uniformity, and in vitro dissolution studies. Characterization in solid state was done by various analytical techniques such as FT-IR studies. Finally by comparing all the formulations, formulation (F3) containing Clobazam +  Povidone  (1:3)  shows better results by solvent evaporation method at the end of 60 min with maximum drug release, hence it was selected as the best  formulation. From the optimized formulation the Fast dissolving tablets were formulated using different disintegrants in different concentrations. The pre compression and post compression parameters were studied and the results were given. All the results are in the acceptable limit. The in vitro drug release of the formulated tablets were performed using 6.8pH buffer. F3C6 formulation containing Lycoat shows 98.02% drug release in 20mins. The optimized formulation follows First order release kinetics.
Keywords: Clobazam, povidone, lycoat, FTIR.