Formulation and Evaluation of Transdermal Patche of Ethanolic Leaves and Flowers Extract of Tridix Procumbens

R. Nandini*, T. Anilkumar, P. Aswini, V. Sreedhar, Naresh Gorantla
Balaji College of Pharmacy, Anantapramu, A.P, India

A B S T R A C T
The skin can be used as the site for drug administration for continuous transdermaldrug infusion in to the systemic circulation. For the continuous diffusion/penetration of the drugs through the intact skin surface membrane-moderated systems, matrix dispersion type systems, adhesive diffusion controlled systems and micro reservoir systems have been developed.  Various penetration enhancers are used for the drug diffusion through skin. In matrix dispersion type system, the drug is dispersed in the solvent along with the polymer and solvent allowed to evaporate forming a homogeneous drug polymer matrix. In the present work, an attempt has been made to develop a matrix type transdermal drug delivery system comprising of ethanolic extract of leaves and flowers of Tridix Procumbens with different ratio of hydrophilic polymer like PEG and EC in combination using solvent evaporation technique. The patches were further subjected to various physical evaluations along with the in-vitro permeation studies using rat skin. On the basis of result obtained from the in-vitro study and physical evaluation the patches containing 1:5 drug to polymer ratio shown good drug releasing characters when compared with the 1:10 and 1:15
Keywords: Transdermal Patches PEG, EC, Matrix-Type, Ethanolic Extract, Tridix Procumbens