Formulation and Evaluation of Taste Masked Rapid Dissolving Tablets of Rizatriptan benzoate

T. Ramchandar^1*, J. Bhaskar², V.L. Narasaiah^3
1Dept. of Pharmaceutics, Mother Teresa College of Pharmacy, Ghatkesar, Hyderabad, Telangana, India.
²Dept. of Pharmaceutics, Avanthi Institute of Pharmaceutical Sciences, Gunthapally, Near Ramoji Film city, Hyderabad, Telangana, India.
³Dept. of Pharmaceutics, Dr Samuel George Institute of Pharmaceutical Sciences, Markapur, A.P, India.

A B S T R A C T
Aim of this research work was to develop mouth dissolving tablet that disintegrates rapidly in mouth by using tasteless complex of Rizatriptan benzoate and Eudragit E 100. Effect of different parameters such as swelling time, drug-Eudragit E ratio as well as stirring time was optimized by taste and percentage drug loading. Formulated DEC (Drug-Eudragit E Complex) was characterized by infrared spectroscopy, thermal analysis. Tablets were formulated by direct compression with Spray dried mannitol SDM as diluent, Indion 234, Sodium Starch Glycolate (SSG) as super disintegrants. In these batches optimum hardness was achieved but disintegration time was found to be very high as ≥ 60 second, so further trials were planned by using different superdisintegrants such as Croscarmellose sodium, Sodium Starch Glycolate (SSG) as well as Indion 234 by direct compression method. Tablets formulated with 4% Indion 234 showed comparatively low disintegration time (26 sec), wetting time (20 sec) and friability (0.56 %) than the other batches. In present study we optimized the conditions required for maximum drug loading of Rizatriptan benzoate with Eudragit E 100. Among different superdisintergants, Indion 234 was found suitable with drug- Eudragit complex to get the low disintegration time, wetting time and friability of tablets. Selected tablets were found stable and followed diffusion controlled first order kinetics. The results revealed that Rizatriptan benzoate was successfully taste masked and formulated into a RDT as an alternative method to conventional tablets.
Keywords: Indion, Rapid-disintegrating tablets, Rizatriptan benzoate, Eudragit, Superdisintegrants.