Formulation and Evaluation of Sustained Release Matrix Tablet of a Model Anti-Hypertensive Drug Using Natural Polymers

K. Navaneetha1*, Y. Upendar Rao2, Dr. B. Venkateswara Reddy1,T. Lavanya1, Ch. Divya1, K. Revanth Chandra1
1Department of Pharmaceutics, St. Pauls College of Pharmacy, Turkayamjal (V), Hayathnagar (M), R.R.Dist, India-501510
2Department of Pharmaceutics, khammam College of Pharmacy, khammam, India

Abstract
The objective of the present study is to develop a sustained release matrix tablets of Losartan potassium, an anti hypertensive drug. The sustained release tablets were prepared by wet granulation and formulated using different drug and polymer ratios, formulations such as F1 to F9. Natural polymers like Xanthan Gum (XG), Guar gum, Cellulose were used. Compatibility of the drug with various excipients was studied. The compressed tablets were evaluated and showed compliance with Pharmacopeial limits. The optimized formulation is F2 on the basis of acceptable tablet properties and in vitro drug release. The resulting formulation produced robust tablets with optimum hardness, consistent weight uniformity and friability. In-Vitro dissolution studies have shown the sustained release for Losartan potassium i.e., 90.88% released at the end of 12h. A decrease in release kinetics of the drug was observed on increasing polymer ratio.
Keywords: Sustain release; Losartan Potassium; Anti Hypertensive; Wet Granulation; Natural Polymers.