Formulation and Evaluation of Omeprazole Buccoadhesive Tablets: Effect of Polymers

ABOUT AUTHOR
S. Prathyusha*, S. Prathima, K. Arshad Ahmed khan, C. Sowmya
Ragavendra Institute of Pharmaceutical Education and Research, Anantapuramu, A.P, India.
*E-mail: prathyusha.siri@gmail.com

Abstract
For the development of omeprazole buccoadhesive tablets, we studied the release and bioavailability of omeprazole delivered by buccal adhesive tablets. These tablets composed of carbopol, xanthum gum, sodium cmc, Hpmc, sodium alginate, croscarmellose sodium. Croscarmellose sodium enhanced the release of omeprazole from the tablets. It may be attached to the human cheek without collapse and it enhanced the stability of omeprazole in human saliva for at least 4 h, giving a fast release of omeprazole. Tablets were prepared by direct compression method and evaluated for buccoadhesive strength and in vitro dissolution parameters. Total twelve formulations were developed with varying concentration of polymers. Formulation F3 showed good buccoadhesive strength. Formulations F1 & F7 showed maximum release 98.75% and 99.96% in 7hrs. The selected best formulations followed zero order drug release pattern. FTIR studies showed no evidence of interaction between drug and polymers. The results indicate the suitable buccoadhesive tablet of Omeprazole with desired property can be prepared.
Keywords: Omeprazole, Buccal adhesive tablet, Sodium cmc, xanthum gum, Dissolution