Formulation and Evaluation of Ocular in Situ Gelling System of Moxifloxacin Hydrochloride

About author
A. Sireesha*, K. Arshad ahmed khan, C. Sowmya
Division of Pharmaceutics,
Raghavendra Institute of Pharmaceutical Education and Research (RIPER),
Anantapur, Andhra Pradesh, India – 515 721.
E-mail: sireesha47@gmail.com

Abstract
The aim of the current study is to design and characterize pH triggered in situ ophthalmic gel forming solution using a fourth generation fluoroquinolone antibiotic, Moxifloxacin hydrochloride. Sodium alginate was used as gelling agent in combination with hydroxyl propyl methyl cellulose (E15LV) as viscosifying agent. Benzalkonium chloride in suitable concentration was used as preservative. Drug-excipient compatibility study was performed by FTIR studies, which indicates no interaction among drug and polymers. The prepared formulations were evaluated for visual appearance, clarity, pH measurement, viscosity, in-vitro gellation study, drug content and in-vitro diffusion studies. The selected formulation showed sustained release for the period of 10 hours thus showing increased residence and contact time with eye. All studies showed favourable results thus in situ gelling system can be considered as alternative for conventional ophthalmic drops.
Keywords: Moxifloxacin Hcl, In-situ gel, viscosifying agent, In Vitro diffusion.